Title : Striatal inhibition of PKA prevents levodopa-induced behavioural and molecular changes in the hemiparkinsonian rat.

Pub. Date : 2010 Apr

PMID : 20060905






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using the 6-hydroxydopamine-lesioned rat model of PD, we showed that l-DOPA elicits profound alterations in the activity of three LID molecular markers, namely DeltaFosB, dopamine, cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) and extracellular signal-regulated kinases 1 and 2 (ERK1/2), as well as in phosphorylation levels of the cytoskeletal-associated protein tau. Levodopa protein phosphatase 1, regulatory (inhibitor) subunit 1B Rattus norvegicus