Pub. Date : 2010 Mar
PMID : 20053791
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells. | Colforsin | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | Overexpression of CREB enhanced forskolin-stimulated Dot1 promoter activity. | Colforsin | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | We conclude that forskolin stimulates CREB-mediated trans-activation of the Dot1 gene, which leads to hypermethylation of histone H3K79 at the CTGF promoter, and inhibition of CTGF transcription. | Colforsin | cAMP responsive element binding protein 1 | Homo sapiens |