Title : The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106.

Pub. Date : 2010 Jan

PMID : 20053762






1 Functional Relationships(s)
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1 This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. gemcitabine tumor protein p53 Homo sapiens