Pub. Date : 2010 Apr
PMID : 20051528
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation. | Leucine | ribosomal protein S6 kinase B1 | Homo sapiens |
| 2 | In wild-type hearts, both leucine and insulin increased p70(S6K) activity whereas, in contrast to insulin, leucine was unable to activate PKB/Akt. | Leucine | ribosomal protein S6 kinase B1 | Homo sapiens |
| 3 | The changes in p70(S6K) activity induced by insulin and leucine correlated with changes in phosphorylation of Thr(389), the mTOR phosphorylation site on p70(S6K), and of Ser(2448) on mTOR, both related to mTOR activity. | Leucine | ribosomal protein S6 kinase B1 | Homo sapiens |
| 4 | The changes in p70(S6K) activity induced by insulin and leucine correlated with changes in phosphorylation of Thr(389), the mTOR phosphorylation site on p70(S6K), and of Ser(2448) on mTOR, both related to mTOR activity. | Leucine | ribosomal protein S6 kinase B1 | Homo sapiens |
| 5 | Moreover, the introduction in PDK1 of the L155E mutation, which is known to preserve the insulin-induced and PKB/Akt-dependent phosphorylation of mTOR/p70(S6K), suppressed all leucine effects, including phosphorylation of mTOR, PRAS40, and p70(S6K). | Leucine | ribosomal protein S6 kinase B1 | Homo sapiens |
| 6 | Moreover, the introduction in PDK1 of the L155E mutation, which is known to preserve the insulin-induced and PKB/Akt-dependent phosphorylation of mTOR/p70(S6K), suppressed all leucine effects, including phosphorylation of mTOR, PRAS40, and p70(S6K). | Leucine | ribosomal protein S6 kinase B1 | Homo sapiens |
| 7 | We conclude that the leucine-induced stimulation of the cardiac PRAS40/mTOR/p70(S6K) pathway requires PDK1 in a way that differs from that of insulin. | Leucine | ribosomal protein S6 kinase B1 | Homo sapiens |