Title : Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.

Pub. Date : 2010 Feb 1

PMID : 20045315






1 Functional Relationships(s)
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1 SAR studies at the lactam nitrogen of the pharmacophore have suggested that a secondary or tertiary amine is important for cellular potency. Amines sarcosine dehydrogenase Homo sapiens