Pub. Date : 2010 Mar
PMID : 20044439
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1-regulated, PKC-dependent, and p38alpha-mediated pathway. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 2 | To profile LPA-induced cytokine production in vascular smooth muscle cells (SMCs), we used a cytokine antibody array system and found that LPA prominently induces the secretion of IL-6 and monocyte chemoattractant protein (MCP)-1 from human aortic SMCs (HASMCs). | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 3 | The present study reveals that LPA induces the expression of IL-6 mRNA and protein in HASMCs as well as the secretion of IL-6 protein in a time-dependent manner. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 4 | The present study reveals that LPA induces the expression of IL-6 mRNA and protein in HASMCs as well as the secretion of IL-6 protein in a time-dependent manner. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 5 | Our results demonstrate that LPA-specific receptor 1 (LPA(1)) mediates LPA-induced IL-6 secretion and that LPA induction of IL-6 is independent of the EGF receptor pathway. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 6 | Our results demonstrate that LPA-specific receptor 1 (LPA(1)) mediates LPA-induced IL-6 secretion and that LPA induction of IL-6 is independent of the EGF receptor pathway. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 7 | Finally, small interfering RNA depletion experiments revealed that p38alpha is specifically responsible for the LPA-induced IL-6 secretion. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 8 | The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 9 | The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 10 | The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 11 | The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 12 | The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. | lysophosphatidic acid | interleukin 6 | Homo sapiens |
| 13 | The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. | lysophosphatidic acid | interleukin 6 | Homo sapiens |