Pub. Date : 2010 Mar
PMID : 20042732
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Shear stress-induced ATP-mediated endothelial constitutive nitric oxide synthase expression in human lymphatic endothelial cells. | Adenosine Triphosphate | nitric oxide synthase 3 | Homo sapiens |
| 2 | Exogenous ATP ranging in concentration from 10(-9) to 10(-6) M produced a significant increase in ecNOS immunohistochemical expression in a dose-dependent manner. | Adenosine Triphosphate | nitric oxide synthase 3 | Homo sapiens |
| 3 | The increase in ecNOS expression mediated by 10(-6)M ATP was significantly reduced by 10(-5) M suramin. | Adenosine Triphosphate | nitric oxide synthase 3 | Homo sapiens |
| 4 | These findings suggest that shear stress produces a significant release of ATP from LEC, which activates the purinergic P2X/2Y receptor, thereby facilitating ecNOS mRNA and protein expression through inositol 1,4,5-trisphosphate-mediated release of intracellular Ca(2+) ions and the activation of Ca(2+)-activated K(+) channels in LEC. | Adenosine Triphosphate | nitric oxide synthase 3 | Homo sapiens |