Title : The hypoxia-inducible factor-2alpha is stabilized by oxidative stress involving NOX4.

Pub. Date : 2010 Aug 15

PMID : 20039838






1 Functional Relationships(s)
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1 Thus, ROS derived from NOX4 in response to thrombin stabilize HIF-2alpha by preventing hydroxylation of the N- and C-TAD, thus allowing formation of transcriptionally active HIF-2alpha, which promotes PASMC proliferation. pasmc coagulation factor II, thrombin Homo sapiens