Pub. Date : 2010 Jan
PMID : 20037485
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The QRT - PCR analysis has shown that, when used simultaneously, DOX 1 microM and SUL 50 microM results in decreased mRNA level for MDR-1 and MRP-1. | Doxorubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 2 | The observed effect is due to quenching of MDR-1 and MRP-1 genes expression, which results in blocking of efflux of DOX outside the cells, which in turn correlates with enhanced apoptotic effects. | Doxorubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |