Title : Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.

Pub. Date : 2010 Feb 15

PMID : 20036328






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Expression of AKR1C3 reduced the anti-proliferative effects of PGD(2) on MCF-7 cells, suggesting that AKR1C3 limits peroxisome proliferator activated receptor gamma (PPARgamma) signaling by reducing formation of 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)). 15-deoxy-delta peroxisome proliferator activated receptor gamma Homo sapiens
2 Expression of AKR1C3 reduced the anti-proliferative effects of PGD(2) on MCF-7 cells, suggesting that AKR1C3 limits peroxisome proliferator activated receptor gamma (PPARgamma) signaling by reducing formation of 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)). 15-deoxy-delta peroxisome proliferator activated receptor gamma Homo sapiens