Title : Neuroprotective properties of mildronate, a mitochondria-targeted small molecule.

Pub. Date : 2010 Feb 12

PMID : 20036318






1 Functional Relationships(s)
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1 In a mouse model of azidothymidine (anti-HIV drug) neurotoxicity, mildronate reduced the azidothymidine-induced alterations in mouse brain tissue: it normalized the increase in caspase-3, cellular apoptosis susceptibility protein (CAS) and iNOS expression assessed by quantitative and semi-quantitative analysis. 3-(2,2,2-trimethylhydrazine)propionate caspase 3 Mus musculus