Pub. Date : 2010 Jan 15
PMID : 20035724
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats. | Cocaine | solute carrier family 6 member 3 | Rattus norvegicus |
| 2 | Cocaine binds with the dopamine transporter (DAT), an effect that has been extensively implicated in its reinforcing effects. | Cocaine | solute carrier family 6 member 3 | Rattus norvegicus |
| 3 | Cocaine binds with the dopamine transporter (DAT), an effect that has been extensively implicated in its reinforcing effects. | Cocaine | solute carrier family 6 member 3 | Rattus norvegicus |
| 4 | However, persisting adaptations in DAT regulation after cocaine self-administration have not been extensively investigated. | Cocaine | solute carrier family 6 member 3 | Rattus norvegicus |
| 5 | Here, we determined the changes in molecular mechanisms of DAT regulation in the caudate-putamen (CPu) and nucleus accumbens (NAcc) of rats with a history of cocaine self-administration, followed by 3weeks of withdrawal under extinction conditions (i.e., no cocaine available). | Cocaine | solute carrier family 6 member 3 | Rattus norvegicus |
| 6 | These results show that chronic cocaine self-administration leads to lasting, regionally specific alterations in striatal DA uptake and DAT-Ser phosphorylation. | Cocaine | solute carrier family 6 member 3 | Rattus norvegicus |