Title : Decoding of lipoprotein-receptor interactions: properties of ligand binding modules governing interactions with apolipoprotein E.

Pub. Date : 2010 Feb 16

PMID : 20030366






3 Functional Relationships(s)
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1 The triple repeat LA3-5 showed the expected interaction with ApoE(1-191).DMPC, but surprisingly CR16-18 did not interact with this form of ApoE. Dimyristoylphosphatidylcholine apolipoprotein E Homo sapiens
2 To understand these differences in ApoE binding affinity, we introduced mutations of conserved residues from LA5 into CR18 and produced a CR16-18 variant capable of binding ApoE(1-191).DMPC. Dimyristoylphosphatidylcholine apolipoprotein E Homo sapiens
3 To understand these differences in ApoE binding affinity, we introduced mutations of conserved residues from LA5 into CR18 and produced a CR16-18 variant capable of binding ApoE(1-191).DMPC. Dimyristoylphosphatidylcholine apolipoprotein E Homo sapiens