Title : Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.

Pub. Date : 2010 Jan 1

PMID : 20028873






2 Functional Relationships(s)
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1 Cytotoxicity assays based on colony formation revealed that LCA exhibits synergism with the alkylating agent temozolomide, which engages BER through DNA methylation, and that the degree of synergism is increased in cells lacking functional BRCA2. Lithocholic Acid BRCA2 DNA repair associated Homo sapiens
2 BRCA2-deficient cells also showed heightened susceptibility to both LCA and temozolomide individually. Lithocholic Acid BRCA2 DNA repair associated Homo sapiens