Pub. Date : 2010 Feb 5
PMID : 20028078
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vav1, whose physiological expression is restricted to hematopoietic system, is one of the signaling proteins up-regulated by all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL)-derived precursors, in which it promotes the overcoming of the differentiation blockade. | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |
| 2 | Vav1, whose physiological expression is restricted to hematopoietic system, is one of the signaling proteins up-regulated by all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL)-derived precursors, in which it promotes the overcoming of the differentiation blockade. | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |
| 3 | Here, we have found that phosphorylation of Vav1 Y174, that is known to regulate Vav1 activity in mature neutrophils, is up-regulated by ATRA in NB4 cells. | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |
| 4 | Here, we have found that phosphorylation of Vav1 Y174, that is known to regulate Vav1 activity in mature neutrophils, is up-regulated by ATRA in NB4 cells. | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |
| 5 | In fact, the overexpression of a mutated form of Vav1, in which Y745 was replaced with a phenylalanine, significantly reduced the ATRA-induced CD11b expression and essentially abrogated the differentiation-related acquisition of the migratory capability. | Tretinoin | vav guanine nucleotide exchange factor 1 | Homo sapiens |