Title : Cytotoxicity of and DNA adduct formation by ellipticine in human U87MG glioblastoma cancer cells.

Pub. Date : 2009

PMID : 20027146






1 Functional Relationships(s)
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1 This effect might be associated with formation of two covalent ellipticine-derived DNA adducts, identical to those formed by 13-hydroxy- and 12-hydroxyellipticine, the ellipticine metabolites generated by CYP1A1, 1B1 and 3A4, lactoperoxidase and cyclooxygenase 1, the enzymes expressed in U87MG cells. ellipticine cytochrome P450 family 1 subfamily A member 1 Homo sapiens