Title : Molecular and tissue responses in the healing of rat calvarial defects after local application of simvastatin combined with alpha tricalcium phosphate.

Pub. Date : 2010 Apr

PMID : 20024970






2 Functional Relationships(s)
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1 Increased upregulation of TGF-beta1 was also observed in the simvastatin group on day 7 (p < 0.05) which was maintained until day 14. Simvastatin transforming growth factor, beta 1 Rattus norvegicus
2 These findings suggest that the proliferation and recruitment of osteoprogenitor cells were critical steps in early stage of bone healing and that these steps were enhanced by TGF-beta1 and BMP-2, which were stimulated by simvastatin. Simvastatin transforming growth factor, beta 1 Rattus norvegicus