Title : Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and beta-lactamase stability on the pKa of the C-7 heterocycle.

Pub. Date : 1991 Mar

PMID : 2002452






5 Functional Relationships(s)
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1 Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Cephalosporins complement C7 Homo sapiens
2 Cephalosporins with new aminobenzimidazole and aminoimidazoline heterocycles at C-7 have been synthesized starting with versatile C-7 isocyanide dihalide synthons. Cephalosporins complement C7 Homo sapiens
3 Cephalosporins with new aminobenzimidazole and aminoimidazoline heterocycles at C-7 have been synthesized starting with versatile C-7 isocyanide dihalide synthons. Cephalosporins complement C7 Homo sapiens
4 Structure-activity relationships are discussed in terms of their dependence on the pKa of the C-7 amino heterocycle, basic C-7 residues giving cephalosporins with exceptional beta-lactamase stability. Cephalosporins complement C7 Homo sapiens
5 Structure-activity relationships are discussed in terms of their dependence on the pKa of the C-7 amino heterocycle, basic C-7 residues giving cephalosporins with exceptional beta-lactamase stability. Cephalosporins complement C7 Homo sapiens