Title : Effects of chronic nicotinic ligand exposure on functional activity of nicotinic acetylcholine receptors expressed by cells of the PC12 rat pheochromocytoma or the TE671/RD human clonal line.

Pub. Date : 1991 Apr

PMID : 2002334






2 Functional Relationships(s)
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1 Chronic (3-72-h) agonist (nicotine or carbamylcholine) treatment of cells led to a complete (TE671) or nearly complete (PC12) loss of functional nAChR responses, which is referred to as "functional inactivation." Carbachol cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
2 Recovery of TE671 cell nAChR function following treatment with carbamylcholine, nicotine, or d-TC occurred with half-times of 1-3 days whether cells were maintained in situ or harvested and replated after removal of ligand. Carbachol cholinergic receptor nicotinic alpha 4 subunit Homo sapiens