Title : Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.

Pub. Date : 2010 Feb 1

PMID : 20022493






1 Functional Relationships(s)
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1 A variety of N-linked tertiary amines and heteroarylamines were examined at the 4-position of sulfonylated proline dipeptides in order to improve VLA-4 receptor off-rates and overcome the issue of CYP3A4 time-dependent inhibition of ester prodrugs. Esters cytochrome P450 family 3 subfamily A member 4 Homo sapiens