Title : Effect of four organophosphorus compounds on human blood acetylcholinesterase: in vitro studies.

Pub. Date : 2006

PMID : 20021020






3 Functional Relationships(s)
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1 The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE. Chlorpyrifos acetylcholinesterase (Cartwright blood group) Homo sapiens
2 The IC50 values for RBC-AChE were 0.12 muM, 0.25 muM, 0.35 muM, and 4.0 muM for chlorpyrifos, monocrotophos, profenofos, and acephate, respectively. Chlorpyrifos acetylcholinesterase (Cartwright blood group) Homo sapiens
3 Chlorpyrifos was found to be a more potent inhibitor of AChE followed by the rest of the pesticides used in this study. Chlorpyrifos acetylcholinesterase (Cartwright blood group) Homo sapiens