Title : Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

Pub. Date : 1991 Mar 15

PMID : 2002019






2 Functional Relationships(s)
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1 As a second approach, we determined whether glucosamine, an agent known to preferentially enter the hexosamine pathway at a point distal to enzymatic amidation by GFAT, could induce cellular insulin resistance. Glucosamine glutamine--fructose-6-phosphate transaminase 1 Homo sapiens
2 Thus, we conclude that glucosamine enters the hexosamine-desensitization pathway at a point distal to GFAT amidation. Glucosamine glutamine--fructose-6-phosphate transaminase 1 Homo sapiens