Title : Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.

Pub. Date : 2010 Aug

PMID : 20020129






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pemetrexed is polyglutamated by the folylpolyglutamate synthase (FPGS) and blocks folate metabolism and DNA synthesis by inhibiting TS, dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT). Folic Acid folylpolyglutamate synthase Homo sapiens