Title : Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells.

Pub. Date : 2010 Mar

PMID : 20019244






2 Functional Relationships(s)
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1 In the present study, we carefully analyzed mRNA expression and activity of the major P450s and their responsiveness to three prototypical inducers, phenobarbital, rifampicin, and omeprazole, in differentiated HepaRG cell cultures over a 4-week period after low and high seeding. Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens
2 Thus, CYP1A2, CYP2B6, and CYP3A4 were found to accurately respond to their respective prototypical inducers, i.e., omeprazole, phenobarbital, and rifampicin. Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens