Pub. Date : 2010 Feb
PMID : 20019189
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis. | Iron | tumor protein p53 | Homo sapiens |
| 2 | Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis. | Iron | tumor protein p53 | Homo sapiens |
| 3 | Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis. | Iron | tumor protein p53 | Homo sapiens |
| 4 | Iron dependent regulation of MDM2/p53 was confirmed ex-vivo in human monocytes, by manipulation of iron pool and in a genetic model of iron deficiency, leading to modulation of p53 target genes involved in the antioxidant response and apoptosis. | Iron | tumor protein p53 | Homo sapiens |
| 5 | Iron status influenced p53 ubiquitination and degradation rate, and the MDM2 inhibitor nutlin increased p53 levels in iron-depleted cells. | Iron | tumor protein p53 | Homo sapiens |
| 6 | Iron status influenced p53 ubiquitination and degradation rate, and the MDM2 inhibitor nutlin increased p53 levels in iron-depleted cells. | Iron | tumor protein p53 | Homo sapiens |
| 7 | The MDM2 -309T > G promoter polymorphism, determining increased MDM2 and lower p53 activity, was associated with higher risk of hepatocarcinoma in cirrhotic patients with hemochromatosis, and with HFE mutations in patients with hepatocarcinoma without hemochromatosis, suggesting an interaction between MDM2 and iron in the pathogenesis of hepatocarcinoma. | Iron | tumor protein p53 | Homo sapiens |
| 8 | In conclusion, iron status influences p53 activity and antioxidant response by modulating MDM2 expression. | Iron | tumor protein p53 | Homo sapiens |