Title : Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4.

Pub. Date : 2010 Jan 15

PMID : 20018613






2 Functional Relationships(s)
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1 In the current study, we demonstrate that incubation of Prx1 with thioglycollate-elicited murine macrophages or immature bone marrow-derived dendritic cells resulted in TLR4-dependent secretion of TNF-alpha and IL-6 and dendritic cell maturation. Thioglycolates toll-like receptor 4 Mus musculus
2 Binding of Prx1 to thioglycollate macrophages occurred within minutes and resulted in TLR4 endocytosis. Thioglycolates toll-like receptor 4 Mus musculus