Title : Vitamin A intake and in vivo expression of the genes involved in retinol transport.

Pub. Date : 1991 Feb 26

PMID : 2001700






3 Functional Relationships(s)
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1 Two different metabolic alterations in vitamin A status are known to cause changes in the amount of circulating retinol-binding protein (RBP) and cellular retinol-binding protein (CRBP) in experimental animals; namely vitamin A deficiency, characterized by depleted retinol-liver stores and hypervitaminosis A, characterized by hepatic accumulation of retinyl esters. Vitamin A retinol binding protein 1 Rattus norvegicus
2 We have found a threefold decrease in the hepatic level of CRBP mRNA in vitamin-A-deficient animals, while the RBP mRNA is not affected by this nutritional deprivation. Vitamin A retinol binding protein 1 Rattus norvegicus
3 The results are discussed in terms of retinol-dependent stabilization of the mRNA coding for CRBP. Vitamin A retinol binding protein 1 Rattus norvegicus