Pub. Date : 2010 Mar
PMID : 20012601
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin. | Lovastatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | BACKGROUND: Lovastatin is an inhibitor of P-glycoprotein (P-gp) and is metabolized by the cytochrome P450 (CYP) 3A4 isoenzyme. | Lovastatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | BACKGROUND: Lovastatin is an inhibitor of P-glycoprotein (P-gp) and is metabolized by the cytochrome P450 (CYP) 3A4 isoenzyme. | Lovastatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSION: Lovastatin increased the absorption of verapamil by inhibiting P-gp and inhibited the first-pass metabolism of verapamil by inhibiting CYP3A4 in the intestine and/or liver in humans. | Lovastatin | ATP binding cassette subfamily B member 1 | Homo sapiens |