Title : Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator.

Pub. Date : 2010 Mar

PMID : 20007670






2 Functional Relationships(s)
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1 CYP1A2, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 were identified as paroxetine-catechol-forming P450 isoforms, and CYP2C19 and CYP2D6 were identified as metabolizing P450 isoforms by substrate depletion. Paroxetine cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 For some individuals CYP1A2 could be of importance for paroxetine metabolism, whereas the importance of CYP2C19 and CYP3A5 is probably limited. Paroxetine cytochrome P450 family 1 subfamily A member 2 Homo sapiens