Pub. Date : 2010 May
PMID : 20005955
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone protects human fibroblasts from apoptosis via an S1P3-receptor subtype dependent activation of PKB/Akt and Bcl XL. | Dexamethasone | BCL2 like 1 | Homo sapiens |
| 2 | Thereupon, Dex not only mediates its anti-apoptotic effect via activation of phosphoinositide 3-kinase (PI3K)/Akt signalling but also includes an involvement of the Bcl-2 family protein Bcl(XL). | Dexamethasone | BCL2 like 1 | Homo sapiens |
| 3 | Most interestingly, the use of S1P(3)-knockout fibroblasts revealed that the S1P(3)-receptor subtype is crucial for activation of PKB/Akt as well as Bcl(XL) by Dex. | Dexamethasone | BCL2 like 1 | Homo sapiens |