Title : Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin.

Pub. Date : 2010 Apr 15

PMID : 20005867






1 Functional Relationships(s)
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1 Pre-treatment with tunicamycin, which inhibits the biosynthesis of N-linked oligosaccharides, decreased the accumulation of Pt in sensitive cells exposed to oxaliplatin or cisplatin and increased the electrophoretic mobility of MRP1 and MRP4, reproducing the association between decreased glycosylation of MRP1 and MRP4 and decreased Pt accumulation observed in the resistant IGROV-1/OHP cells. n-linked oligosaccharides ATP binding cassette subfamily C member 1 Homo sapiens