Title : In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study.

Pub. Date : 2010 Jun

PMID : 20004922






1 Functional Relationships(s)
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1 The rank order of selectivity for inhibition of COX-2 versus COX-1 (IC(50) COX-1:IC(50) COX-2) for veterinary drugs was highest with robenacoxib (128.8) compared to deracoxib (48.5), nimesulide (29.2), S+ carprofen (17.6), meloxicam (7.3), etodolac (6.6), R- carprofen (5.8) and ketoprofen (0.88). nimesulide cytochrome c oxidase subunit I Canis lupus familiaris