Pub. Date : 1991 Feb
PMID : 2000226
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By selective oligonucleotide hybridization of polymerase chain reaction (PCR) amplified tumor DNAs we have analysed the incidence of mutations at codon 61 of the Ha-ras gene in 42 liver tumors spontaneously developed in Balb/c, C3Hf and B6C3 male mice, and in 79 liver tumors induced by the chemical carcinogens diethylnitrosamine (NDEA) and urethan in B6C3 and B6C male and female mice. | Diethylnitrosamine | Harvey rat sarcoma virus oncogene | Mus musculus |
| 2 | By selective oligonucleotide hybridization of polymerase chain reaction (PCR) amplified tumor DNAs we have analysed the incidence of mutations at codon 61 of the Ha-ras gene in 42 liver tumors spontaneously developed in Balb/c, C3Hf and B6C3 male mice, and in 79 liver tumors induced by the chemical carcinogens diethylnitrosamine (NDEA) and urethan in B6C3 and B6C male and female mice. | Diethylnitrosamine | Harvey rat sarcoma virus oncogene | Mus musculus |
| 3 | NDEA-induced tumors showed a low incidence of Ha-ras mutations in both the hybrid mice (3/18 and 1/13 in B6C3 and B6C male mice, respectively). | Diethylnitrosamine | Harvey rat sarcoma virus oncogene | Mus musculus |
| 4 | Our results indicate that liver tumors induced by NDEA or urethan or spontaneously arisen have a different pattern of Ha-ras mutations at codon 61 and that these mutations constitute a rare molecular alteration in the pathogenesis of liver tumors in genetically resistant mice. | Diethylnitrosamine | Harvey rat sarcoma virus oncogene | Mus musculus |