Pub. Date : 1991 Feb
PMID : 2000226
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By selective oligonucleotide hybridization of polymerase chain reaction (PCR) amplified tumor DNAs we have analysed the incidence of mutations at codon 61 of the Ha-ras gene in 42 liver tumors spontaneously developed in Balb/c, C3Hf and B6C3 male mice, and in 79 liver tumors induced by the chemical carcinogens diethylnitrosamine (NDEA) and urethan in B6C3 and B6C male and female mice. | Urethane | Harvey rat sarcoma virus oncogene | Mus musculus |
| 2 | The incidence of Ha-ras gene mutations in both spontaneously developed and urethan-induced liver tumors was 50%-63% in mice genetically susceptible to hepatocarcinogenesis (C3Hf, B6C3) and 7%-9% in mice genetically resistant (Balb/c, B6C). | Urethane | Harvey rat sarcoma virus oncogene | Mus musculus |
| 3 | Our results indicate that liver tumors induced by NDEA or urethan or spontaneously arisen have a different pattern of Ha-ras mutations at codon 61 and that these mutations constitute a rare molecular alteration in the pathogenesis of liver tumors in genetically resistant mice. | Urethane | Harvey rat sarcoma virus oncogene | Mus musculus |