Pub. Date : 2010 Feb 1
PMID : 19998410
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes. | Dinoprostone | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | PGE2 suppressed the phosphorylation of JNK and ERK MAP kinases, but only knockdown of JNK by specific siRNA mimicked the effect of PGE2. | Dinoprostone | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | PGE2 suppressed the phosphorylation of JNK and ERK MAP kinases, but only knockdown of JNK by specific siRNA mimicked the effect of PGE2. | Dinoprostone | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | These results demonstrate that PGE2 inhibits IL-1beta-induced MMP-1 and MMP-13 productions via EP4 by suppressing MKK4-JNK MAP kinase-c-JUN pathway. | Dinoprostone | mitogen-activated protein kinase 8 | Homo sapiens |