Title : Molecular mechanism for human sperm chemotaxis mediated by progesterone.

Pub. Date : 2009 Dec 8

PMID : 19997608






1 Functional Relationships(s)
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1 Our data implicate a number of classic signal transduction pathways in the response and provide a model for the sequence of events, where the tmAC-cAMP-PKA pathway is activated first, followed by protein tyrosine phosphorylation (equatorial band and flagellum) and calcium mobilization (through IP(3)R and SOC channels), whereas the sGC-cGMP-PKG cascade, is activated later. Cyclic AMP protein kinase cGMP-dependent 1 Homo sapiens