Title : The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors.

Pub. Date : 1991 Feb

PMID : 1995415






4 Functional Relationships(s)
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1 We find that induction by cycloheximide is due to stabilization of c-myc transcripts. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 The requirements for increased expression of c-myc mRNA by cycloheximide are the presence of the sequence encoding c-myc amino acids 335-439 on a mRNA that can be translated; all other portions of the c-myc gene are dispensable, and this sequence can confer induction of mRNA expression by protein synthesis inhibitors on a heterologous gene. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens
3 The requirements for increased expression of c-myc mRNA by cycloheximide are the presence of the sequence encoding c-myc amino acids 335-439 on a mRNA that can be translated; all other portions of the c-myc gene are dispensable, and this sequence can confer induction of mRNA expression by protein synthesis inhibitors on a heterologous gene. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens
4 The requirements for increased expression of c-myc mRNA by cycloheximide are the presence of the sequence encoding c-myc amino acids 335-439 on a mRNA that can be translated; all other portions of the c-myc gene are dispensable, and this sequence can confer induction of mRNA expression by protein synthesis inhibitors on a heterologous gene. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens