Title : The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.

Pub. Date : 2009 Dec

PMID : 19952119






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In cells, the free base of IPI-504 hydroquinone exists in a dynamic redox equilibrium with its corresponding quinone (17-AAG); the hydroquinone form binding 50 times more tightly to Hsp90. quinone N-methylpurine DNA glycosylase Homo sapiens