Pub. Date : 2010 Feb 12
PMID : 19946124
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Beta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzyme. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 2 | Site-directed mutagenesis of the actin-binding domain of eNOS replacing leucine and tryptophan with alanine yielded an eNOS mutant that exhibited reduced eNOS-beta-actin association, decreased NO production, and increased superoxide formation in COS-7 cells. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 3 | Site-directed mutagenesis of the actin-binding domain of eNOS replacing leucine and tryptophan with alanine yielded an eNOS mutant that exhibited reduced eNOS-beta-actin association, decreased NO production, and increased superoxide formation in COS-7 cells. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 4 | Site-directed mutagenesis of the actin-binding domain of eNOS replacing leucine and tryptophan with alanine yielded an eNOS mutant that exhibited reduced eNOS-beta-actin association, decreased NO production, and increased superoxide formation in COS-7 cells. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 5 | Disruption of eNOS-beta-actin interaction in endothelial cells using ABS peptide 326 resulted in decreased NO production, increased superoxide formation, and decreased endothelial monolayer wound repair, which was prevented by PEG-SOD and NO donor NOC-18. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 6 | Taken together, this novel finding indicates that beta-actin binding to eNOS through residues 326-333 in the eNOS protein results in shifting the enzymatic activity from superoxide formation toward NO production. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 7 | Taken together, this novel finding indicates that beta-actin binding to eNOS through residues 326-333 in the eNOS protein results in shifting the enzymatic activity from superoxide formation toward NO production. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 8 | Modulation of NO and superoxide formation from eNOS by beta-actin plays an important role in endothelial function. | Superoxides | nitric oxide synthase 3 | Homo sapiens |