Title : Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain.

Pub. Date : 2010 Mar 19

PMID : 19944723






2 Functional Relationships(s)
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1 In these cells, HMGB1 siRNA delivery successfully reduced both basal and H(2)O(2)- or NMDA-induced HMGB1 levels, and as a result of that, neuronal cell death was significantly suppressed in both cases. Hydrogen Peroxide high mobility group box 1 Rattus norvegicus
2 In these cells, HMGB1 siRNA delivery successfully reduced both basal and H(2)O(2)- or NMDA-induced HMGB1 levels, and as a result of that, neuronal cell death was significantly suppressed in both cases. Hydrogen Peroxide high mobility group box 1 Rattus norvegicus