Title : Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents.

Pub. Date : 2010 May

PMID : 19942932






1 Functional Relationships(s)
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1 The JNK inhibitor SP600125 abrogated MIA-induced mitotic arrest and downregulation of cFLIP and Mcl-1 and reduced the apoptosis caused by the combination of MIAs and TRAIL. pyrazolanthrone TNF superfamily member 10 Homo sapiens