Pub. Date : 2010 Mar
PMID : 19942609
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. | Reactive Oxygen Species | proline dehydrogenase 1 | Homo sapiens |
| 2 | To elucidate the role of POX in oxLDL-mediated cytotoxicity, we knocked down POX via small interfering RNA and found that this (i) further reduced viability of cancer cells treated with oxLDL; (ii) decreased oxLDL-associated reactive oxygen species generation; (iii) decreased autophagy measured via beclin-1 protein level and light-chain 3 protein (LC3)-I into LC3-II conversion. | Reactive Oxygen Species | proline dehydrogenase 1 | Homo sapiens |