Title : Glypican-1 mediates both prion protein lipid raft association and disease isoform formation.

Pub. Date : 2009 Nov

PMID : 19936054






2 Functional Relationships(s)
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1 We then utilised a transmembrane-anchored form of PrP (PrP-TM), which is targeted to rafts solely by its N-terminal domain, to show that both heparin and phosphatidylinositol-specific phospholipase C can inhibit its association with detergent-resistant rafts, implying that a GPI-anchored HSPG targets PrP(C) to rafts. Phosphatidylinositols prion protein Mus musculus
2 We then utilised a transmembrane-anchored form of PrP (PrP-TM), which is targeted to rafts solely by its N-terminal domain, to show that both heparin and phosphatidylinositol-specific phospholipase C can inhibit its association with detergent-resistant rafts, implying that a GPI-anchored HSPG targets PrP(C) to rafts. Phosphatidylinositols prion protein Mus musculus