Title : Antifibrotic effect by activation of peroxisome proliferator-activated receptor-gamma in corneal fibroblasts.

Pub. Date : 2009 Nov 10

PMID : 19936025






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1 RESULTS: Treatment with pioglitazone at concentrations ranging from 1 to 10 mum significantly decreased corneal fibroblast migration, as determined by scrape-wound assay, inhibited corneal fibroblast-induced collagen lattice contraction, and reduced MMP-2 and MMP-9 secretion into the supernatant of cell cultures in a dose-dependent manner. Pioglitazone 72 kDa type IV collagenase Oryctolagus cuniculus