Title : Ras-induced invasion and metastasis are regulated by a leukotriene B4 receptor BLT2-linked pathway.

Pub. Date : 2010 Feb 25

PMID : 19935719






2 Functional Relationships(s)
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1 Here, we demonstrate that a novel BLT2, a low-affinity leukotriene B(4) receptor-linked signaling cascade involving the generation of reactive oxygen species (ROS) via Nox1, NF-kappaB stimulation and subsequent upregulation of matrix metalloproteinase-9 (MMP-9) is a potential mechanism by which Ras promotes invasion and metastasis. Reactive Oxygen Species NADPH oxidase 1 Mus musculus
2 Here, we demonstrate that a novel BLT2, a low-affinity leukotriene B(4) receptor-linked signaling cascade involving the generation of reactive oxygen species (ROS) via Nox1, NF-kappaB stimulation and subsequent upregulation of matrix metalloproteinase-9 (MMP-9) is a potential mechanism by which Ras promotes invasion and metastasis. Reactive Oxygen Species NADPH oxidase 1 Mus musculus