Title : A correlation between GM-CSF gene expression and metastases in murine tumors.

Pub. Date : 1991 Feb 1

PMID : 1993549






2 Functional Relationships(s)
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1 GM-CSF mRNA was, however, detected in the tumor cells in the presence of an mRNA-stabilizing agent, cycloheximide, suggesting the possibility that the tumor cells of this type were transcribing GM-CSF gene, and secreting it in undetectable levels; (3) in culture of the 4 remaining poorly or non-metastatic tumors, neither CSF activity nor GM-CSF mRNA could be detected even in the presence of cycloheximide. Cycloheximide colony stimulating factor 2 (granulocyte-macrophage) Mus musculus
2 GM-CSF mRNA was, however, detected in the tumor cells in the presence of an mRNA-stabilizing agent, cycloheximide, suggesting the possibility that the tumor cells of this type were transcribing GM-CSF gene, and secreting it in undetectable levels; (3) in culture of the 4 remaining poorly or non-metastatic tumors, neither CSF activity nor GM-CSF mRNA could be detected even in the presence of cycloheximide. Cycloheximide colony stimulating factor 2 (granulocyte-macrophage) Mus musculus