Title : Reactivity of 6-halopurine analogs with glutathione as a radiotracer for assessing function of multidrug resistance-associated protein 1.

Pub. Date : 2009 Nov 26

PMID : 19921956






3 Functional Relationships(s)
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Protein Name
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1 6-Bromo-7-[(11)C]methylpurine is reported to react with glutathione via glutathione S-transferases in the brain and to be converted into a substrate for multidrug resistance-associated protein 1 (MRP1), an efflux pump. 6-bromo-7-methylpurine ATP binding cassette subfamily C member 1 Homo sapiens
2 6-Bromo-7-[(11)C]methylpurine is reported to react with glutathione via glutathione S-transferases in the brain and to be converted into a substrate for multidrug resistance-associated protein 1 (MRP1), an efflux pump. 6-bromo-7-methylpurine ATP binding cassette subfamily C member 1 Homo sapiens
3 In conclusion, the adjustment of reactivity of 6-bromo-7-[(11)C]methylpurine may allow assessment of MRP1 function in the brain in various species. 6-bromo-7-methylpurine ATP binding cassette subfamily C member 1 Homo sapiens