Title : Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney.

Pub. Date : 2010 Feb 4

PMID : 19920212






1 Functional Relationships(s)
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1 We identified novel ACTH-induced changes in 1) genes involved in vitamin D (Cyp27b1, Cyp24a1, Gc) and calcium (Sgk, Calb1, Trpv5) metabolism associated with calciuria and phosphaturia; 2) genes that would be predicted to desensitize the kidney to glucocorticoid action (Nr3c1, Hsd11b1, Fkbp5); and 3) genes encoding transporters of enzyme systems associated with xenobiotic metabolism and oxidative stress. Vitamin D cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus