Title : Inositol hexaphosphate suppresses growth and induces apoptosis in prostate carcinoma cells in culture and nude mouse xenograft: PI3K-Akt pathway as potential target.

Pub. Date : 2009 Dec 15

PMID : 19920184






1 Functional Relationships(s)
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1 These findings suggest that, by targeting the PI3K-ILK1-Akt pathway, IP6 suppresses cell survival, proliferation, and angiogenesis but induces death in prostate cancer cells, which might have translational potential in preventing and controlling the growth of advanced and aggressive prostate cancer for which conventional chemotherapy is not effective. Phytic Acid phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens