Title : Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.

Pub. Date : 2010 Jan 22

PMID : 19920149






1 Functional Relationships(s)
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1 The physical association between PDK1 and ASK1 is mediated through the pleckstrin homology domain of PDK1 and the C-terminal regulatory domain of ASK1 and is decreased by ASK1-activating stimuli, such as H(2)O(2), tumor necrosis factor alpha, thapsigargin, and ionomycin, as well as insulin, a PDK1 stimulator. Ionomycin tumor necrosis factor Homo sapiens